会员登录信息
您好,欢迎光临珠宝网上商城。  [请登录] [免费注册]
热卖商品: 粉色花衬衫  |  深棕色皮鞋  |  桑蚕丝帕巾  |  桑蚕丝帕巾  | 
网站标志
购物车
购物车中共有 0 件商品
共计:0.00
查看购物车
当前位置
点评详情
发布于:2018-3-9 15:26:36  访问:2 次 回复:0 篇
版主管理 | 推荐 | 删除 | 删除并扣分
3). Measuring the secreted alkaline phosphatase levels (Se AP) in blood (succeeded
Comment (ref.) Intervention (ref.) Outcome (ref.)LGMDAnimal modelDescriptionLGMD1A ERK inhibition (PD98059) (54)LGMD1BReverse DCM in miceLGMD1C Myostatin (M) inhibition (55) TGF- receptor inhibitor (59) AAV delivery mutated (M) (56) AAV delivery calpain three (60) Diltiazem (61), Ng formal selection assistance capabilities (www.mcdmsociety.org/soft.html). Instructors pyridostigmine (62) Dual AAV gene transfer (63) HUCB i.v. administration (64) Q10 and resveratrol (65)Myo-/Myo+/T57I DTg LmnaH222P/H222P Lmna-/Cav-3-/Cav-3+/P104LKnockout mouse Transgenic mouse Double transgenic Knockin mouse Knockout mouse Knockout mouse Transgenic mouseNormal Phenotype related to myotilinopathy Much more serious phenotype than TgT57I, Tg WT Extra relevant to human laminopathy Significantly less relevant to human laminopathy Muscle illness, HCM, defect in T-tubulesLGMD2ARevere atrophy, weakness Revere atrophy, weakness Revese atrophy, weakness Revese atrophy, weakness Improved contractile function Clinical, biochemical imp. Biochemical imp. Histological impLGMD2BCapn3C129S/C129S Capn3-/Capn3 Tg A/J B6.A/J SJL/JKnockin mouse Knockout mouse Transgenic mouse Spontaneous By breeding SpontaneousProteolytically inactive, structurally intact No calpain-3 Regular Retrotransposon insertion in intron four Retrotransposon insertion in intron four Re linked using a a lot more anti-inflammatory blood leukocyte gene expression profile Splice internet site mutation at exonLGMD2C Lacking each integrin 7 and -sarcoglycanB10.SJL Dysf-/gsg-/-By breeding Knockout mouse Knockout mouseSplice web page mutation at exon 45 Deletion of exon 45 Exon 2 disruptionMOLECULAR MEDICINE REPORTS 9: 1515-1532,LGMD2D Standard Exon two disruptiongxi Sgca-/-Double knockout Knockout mouseGenetic disruption of C3 (57) AAV gene transfer (66) Myostatin blockade (67) Integrin 71 (68) AAV gene transfer (69) Mesoangioblasts i.a. (70) Deacetylase inhibitors (71)Enhanced muscle pathology Biochemical imp. Increase function not histology Compensate -sarcoglycan Biochemical imp. Biochemical imp. Reverse morphology, functionLGMD2E LGMD2FSGCAH77C/H77C Sgcb-/BIO14.Knockin mouse Knockout mouse SpontaneousTO-2 Exon two targeted replacementBy breedingSgcd-/-KnockdownAAV gene transfer (72) AAV gene transfer (73) Tranilast, diltiazem (74) AAV gene transfer (75) HUCB i.myo. administration (76) Hematopoietic stem cells (77) Myosphere-derived progenitors (78) Myostatin blockade (79) AAV gene transfer (80)Biochemical imp. Reverse morphology, function Biochemical imp. Biochemical and functional Short-term imp. No imp. Enhanced heart function Early-stage imp. Heart but not muscle imp.LGMD, limb-girdle muscular dystrophies; C3, complement component C3; HUCB, human umbilical cord blood; imp., improvement; ref, reference; i.v., intravenous; i.a., intra arterial; i.myo., intramuscular; AAV, adeno-associated virus; DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy.Table III. Continued. Comment Intervention ResultLGMDAnimal modelDescriptionLGMD2G LGMD2H Carries c.1459G>A, p. D487N mutation Wild allele compensate mutated 1 Lethal at E9.five PEVK part of TTN extremely phosphorylated Calcium-sensitive region of TTN C-terminal region of TTN (homo. Het.) FINmaj (Het.) X capn3? ice (81)LGMD2JLGMD2L Dystroglycan Substantial gene mutatedTCap-/Trim32-/T32KI TTN+/c.43628insAT TTNhom PEVK-/N2B-/FINmaj No jir.2010.0097 model but Massive gene transfer (82)Knockout mouse Knockout mouse Knockin mouse Knockin mouse (.3). Measuring the secreted alkaline phosphatase levels (Se AP) in blood (succeeded in murine models), involves insertion of your secreted alkaline phosphatase gene with all the gene of interest 1568539X-00003152 into a viral vector. Following this,Table III. Murine models with assumed therapy. Comment (ref.) Intervention (ref.) Outcome (ref.)LGMDAnimal modelDescriptionLGMD1A ERK inhibition (PD98059) (54)LGMD1BReverse DCM in miceLGMD1C Myostatin (M) inhibition (55) TGF- receptor inhibitor (59) AAV delivery mutated (M) (56) AAV delivery calpain 3 (60) Diltiazem (61), pyridostigmine (62) Dual AAV gene transfer (63) HUCB i.v.
共0篇回复 每页10篇 页次:1/1
共0篇回复 每页10篇 页次:1/1
我要回复
回复内容
验 证 码
看不清?更换一张
匿名发表 
脚注信息
Copyright ? 2015-2016 All Rights Reserved. 定啦定制平台官方网站 版权所有   浙ICP备2597841
服务时间:周一至周六  10:00-18:00  全国订购及服务热线:400 087 7921
联系地址:杭州市江干区九盛路9号东方电子商务园16幢5楼  邮政编码:310000