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发布于:2018-3-9 15:27:04  访问:14 次 回复:0 篇
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GT activity is superior to serum GGT activity in other illnesses
KKaw performed experiments, analyzed data and wrote the manuscript. YF contributed to evaluation and interpretation of information. YM and TA performed immunohistochemical analysis. KMi directed sample collection and analyzed data and KH, KKam, TK KMa, YK, MT and TD contributed to sample collection and interpretation of information. All authors reviewed the manuscript and approved the final version. Competing interests The authors declare that they have no competing interests. Consent for publication Not applicable. Ethics approval and consent to participate This study was authorized by the Bioethics Committees of Gifu University and Tokyo Metropolitan Institute of Gerontology and a written informed consent was obtained from all patients. We demonstrated that GGT activity in serum exosomes was substantially higher in Computer individuals than in BPH individuals, which was supported by enhanced GGT expression in Pc tissues compared with BPH tissues. Serum exosomal GGT activity may be a beneficial marker to diagnose Computer or to distinguish Computer from BPH and possibly to diagnose other kinds of cancer with improved GGT expression.Publisher‘s NoteSpringer Nature remains neutral with regard to jurisdictional claims in Title Loaded From File published maps and institutional affiliations.The prognostic significance of.GT activity is superior to serum GGT activity in other diseases than Computer. Nonetheless, in order to conduct largescale research, a easy and fast detection technique remains to become established, which would make it achievable to evaluate the possible of serum exosomal GGT activity as prognostic as well as diagnostic markers in prospective clinical research. Ultimately, it‘s also of great importance to understand the properties and roles of GGT on exosomes in serum of patients.Extra filesAdditional file Table S. List of differentially expressed proteins. (PDF kb) More file Fig. S. GGT activity in exosomes isolated by differential centrifugation from serum of Computer patients. (PDF kb) Added file Table S. Patient qualities. (PDF kb) More file Fig. S. ROC curve analysis of Pc and BPH individuals. (PDF kb) Abbreviations BPHBenign prostatic hyperplasia; CHCChronic hepatitis C; CRPCCastrationresistant prostate cancer; EVExtracellular vesicles; gGluHMRGglutamyl hydroxymethyl rhodamine green; GGTGammaglutamyltransferase ; GSHGlutathione; MDRMultidrug resistance protein ; NAFLDNonalcoholic fatty liver disease; PCProstate cancer; PCAProstate cancer antigen ; PgpPglycoprotein; PSAProstatespecific antigen; PSMAProstatespecific membrane antigen; PVDFPolyvinylidene difluoride; GluAMCgammaglutamylamidomethylcoumarin We thank Mr. Tsuyoshi Maruyama at Tokyo Metropolitan Geriatric Hospital and Mr. Yasuo Hasegawa at Tokyo Metropolitan Institute of Gerontology for their technical help. We also thank Drs. Hiroki Tsumoto and Yuri Miura at Tokyo Metropolitan Institute of Gerontology for their help in proteomic evaluation. Funding This perform was supported in part by the GrantinAid from the Ministry of Education, Culture, Sports, Science, and Technologies of Japan (BH to MI). The funding body did not take part in the style of the study and collection, analysis, and interpretation of information and in writing the manuscript. Availability of information and supplies The datasets supporting the of this short article are incorporated within the report. Any request of data and material may well be sent to the corresponding author. Authors‘ contributions MI conceived of and directed the project and wrote the manuscript. KKaw performed experiments, analyzed information and wrote the manuscript. YF contributed to analysis and interpretation of data. YM and TA performed immunohistochemical analysis. KMi directed sample collection and analyzed information and KH, KKam, TK KMa, YK, MT and TD contributed to sample collection and interpretation of data.
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