会员登录信息
您好,欢迎光临珠宝网上商城。  [请登录] [免费注册]
热卖商品: 粉色花衬衫  |  深棕色皮鞋  |  桑蚕丝帕巾  |  桑蚕丝帕巾  | 
网站标志
购物车
购物车中共有 0 件商品
共计:0.00
查看购物车
当前位置
点评详情
发布于:2018-5-17 23:39:31  访问:15 次 回复:0 篇
版主管理 | 推荐 | 删除 | 删除并扣分
Ng liver. Aging. 2009; 1: 582-585. 406. Gan B, DePinho RA. mTORC1 signaling governs
J Natl Cancer Inst. 2000; 92: 1252-1259. 410. Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA. 2001; 98: 10314-10319.www.impactjournals.com/oncotargetOncotarget 2012; 3: 954-
PIK3CA MK-571 (sodium salt) web mutations Chaetocin dose frequently occur in diverse cancers and are associated with constitutive activation of the PI3K/AKT/mTOR pathway.[1-5] In addition, PIK3CA mutations predicted sensitivity to PI3K/AKT/www.impactjournals.com/oncotargetmTOR inhibitors in multiple tumor types in preclinical and early clinical experiments.[1, 2, 5-12] A seminal question is whether PIK3CA mutations are associated with a distinct phenotypic taxonomy. Retrospective studies in colorectal cancer demonstrated that PIK3CA mutations in exon 20 encoding for the kinase domain, but not in exonOncotarget2012;3:123456-9 encoding for the helical domain, are associated with resistance to EGFR-targeting monoclonal antibodies. [13] In addition, our group reported that, regardless of histology, PIK3CA mutations often coexist with mitogenactivated protein kinase (MAPK) mutations, such as mutated KRAS, NRAS, and BRAF.[14] A partial answer to the question posed about the relationship between PIK3CA mutations and specific subtypes of cancer is generally that different cancers seem to have different types of PIK3CA mutations and associations with still other mutations.[15] For example, in colorectal cancer PIK3CA mutations in exon 9, but not exon 20, trended toward an association with KRAS mutations, whereas only PIK3CA exon 20 mutations were associated with KRAS mutations in ovarian cancer.[13, 16] Other oncogenic mutations have also been correlated with clinical characteristics and outcome. For example patients with advanced cancers and BRAF mutations have less soft tissue, retroperitoneal, lung metastases and more brain metastases.[17] In colorectal cancer, BRAF mutations predicted poor outcome and KRAS mutations were associated with lung metastases. [13, 18] We investigated characteristics and outcomes of patients with advanced cancers with and without PIK3CA mutations.Tissue samples and mutation analysesPIK3CA, KRAS, fpsyg.2016.00135 NRAS, and BRAF mutations were investigated in archival formalin-fixed, paraffin-embedded tissue blocks or material from primary or metastatic lesions obtained from diagnostic and/or therapeutic procedures. All histologies were centrally reviewed at MD Anderson. Mutation testing was performed in the Clinical Laboratory Improvement Amendment?certified Molecular Diagnostic Laboratory within the Division of Pathology and Laboratory Medicine at MD Anderson. DNA was extracted from microdissected paraffin-e.Ng liver. Aging. 2009; 1: 582-585. 406. Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. j.cub.2015.05.021 Cell Cycle. 2009; 8: 1003-1006. 407. Lluis F, Cosma MP. Somatic cell reprogramming control: signaling pathway modulation versus transcription factor activities. Cell Cycle. 2009; 8: 1138-1144. 408. Wu GJ, Sinclair CS, Paape J, Ingle JN, Roche PC, James CD, Couch FJ. 17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K and SIGma1B genes. Cancer Res. 2000; 60: 5371-5375. 409. Barlund M, Forozan F, Kononen J, Bubendorf L, Chen Y, Bittner ML, Torhorst J, Haas P, Bucher C, Sauter G, Kallioniemi OP, Kallioniemi A. Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis. J Natl Cancer Inst. 2000; 92: 1252-1259. 410. Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL.
共0篇回复 每页10篇 页次:1/1
共0篇回复 每页10篇 页次:1/1
我要回复
回复内容
验 证 码
看不清?更换一张
匿名发表 
脚注信息
Copyright ? 2015-2016 All Rights Reserved. 定啦定制平台官方网站 版权所有   浙ICP备2597841
服务时间:周一至周六  10:00-18:00  全国订购及服务热线:400 087 7921
联系地址:杭州市江干区九盛路9号东方电子商务园16幢5楼  邮政编码:310000